This study was conducted for a Comparative Evaluation of Five Obturation Techniques in the Management of Simulated Internal Resorptive Cavities. Material and methods: Fifty human maxillary central incisors with fully developed root apices that had just been extracted were gathered. For this study, teeth without internal resorption, calcification, or a root canal filling were selected. The roughly 21 mm teeth that were found were cleaned with ultrasonic technology to remove calculus and debris. They were then stored in a saline solution. A size 10 K-file was inserted into each tooth's prepared endodontic access to locate the apical foramen. After the teeth were instrumented using a master apical file size 40 and the step-back procedure up to size 80, they were finally irrigated with saline and 2.5% sodium hypochlorite solution. SPSS software was used for statistical analysis. Results: In this study, comparing group C for Obtura II with System B, group D for E as well as Q plus with System B, group E for Thermafil, as well as groups A & B for warm vertical compaction and B for lateral condensation, it was statistically significant (P=0.000) that group C displayed the highest percentage of gutta-percha plus sealer and gutta-percha and the fewest voids. Table 1 also showed that Group B had a significantly larger percentage of sealers (P<0.0001). Additionally, compared to all other groups, Group E exhibits a considerably larger void percentage (P<0.0001). Conclusion: It has been determined that combined Obtura II and System B is the most effective obturation technique for teeth exhibiting internal resorption. Thermafil yielded the lowest quality of obturation when used to treat teeth with internal resorption. Likewise, the lateral condensation technique demonstrated the highest sealer, indicating that it is not suitable for treating internal resorptive cavities.