Triazoles, nitrogen-containing heterocyclic molecules, have demonstrated effectiveness in various pharmaceutical applications. Structurally, five-membered triazoles are categorized into two types: 1,2,3-triazoles and 1,2,4-triazoles. These triazoles can undergo electrophilic and nucleophilic substitutions around their basic structures, enabling the synthesis of new bioactive compounds. Triazoles and their analogues exhibit diverse biological properties, including antibacterial, anticancer, anti-infective, anti-Alzheimer's, antibiofilm, and more. They also play essential roles in organocatalysis, agriculture, and the textile industry. However, to achieve greater efficacy with fewer side effects, the azole family has undergone careful revision due to adverse events such as hepatotoxicity and hormonal issues. Triazoles have indeed been the foundation for numerous effective medications, including fluconazole and ketoconazole, which are widely used to treat fungal infections. The synthesis of triazole scaffolds has attracted considerable interest due to their importance in medicinal chemistry. This review focuses on several key aspects, including the medicinal uses of triazoles, their synthesis methods, the development of versatile hybrid molecules, and their structural characteristics.Understanding these facets can provide valuable insights into the diverse pharmacological applications and synthetic strategies involving triazoles and related compounds.