Introduction:The metabolic syndrome is a combination of insulin resistance, visceral adiposity, dyslipidemia and hypertension, which are interrelated. One important use of metabolic syndrome is clinical assessment of patients, in identifying patients with high risk of Non- Alcoholic Fatty Liver Disease(NAFLD)Type 2 Diabetes Mellitus(T2DM) or Cardiovascular Disease(CVD) Materials & Methods: This is a cross- sectional study conducted among 150 patients admitted in a tertiary care centre in Chengalpattu district. All the study participants underwent clinical examinations, anthropometric measurements and laboratory investigations to be diagnosed a metabolic syndrome as per NCEP: ATP III criteria. Results: The prevalence of Metabolic syndrome was found to be 26%. Only educational status had association (p value <0.001) with Liver enzymes in our study. Metabolic syndrome had significant association with AST/ ALT ratio with p value of 0.001. Conclusion:Our study had Liver enzymes strongly correlated with Metabolic syndrome. Since NAFLD is more prevalent in Metabolic syndrome patients, these liver enzymes play a major role in identifying patients with NAFLD which is early predictor of cardiovascular diseases.