When someone gets sick with Plasmodium falciparum, they can get cerebral malaria, which is a major public health problem. The patient died, became unconscious, and went into a coma because brain malaria infected his red blood cells, platelets, and white blood cells. Artemether has artemisinin in it, which kills Plasmodium falciparum parasites very well. The artemisia annua plant makes artemether, which is a chemical that is used to treat cancer. Artemisinin, one of its products, is approved to treat some types of colon cancer, melanoma, leukemia, and breast cancer. Artemether is also used to treat parasitic infections in the brain. It is a Bcs Class IV drug because its half-life is only three to five hours and it doesn't dissolve well in water. So, to get around this problem, look into other ways to use ARM to send drugs from the nose to the brain. Normal ways of giving this medicine don't work for treating cerebral malaria because they send the medicine into the bloodstream instead of straight to the brain. Because of this, it doesn't work to treat CM. It is necessary to send ARM for CM through the nose to the brain in order for it to work well. According to a recent study, three different carriers are used to put drugs inside a proniosome. This makes sure that the drugs are the right size for best release and success in trapping the drug. We use lactose that has had its surface changed, along with a certain carrier called Neusilin. Surface modification is a good thing that can change the qualities of adhesion and cohesion, improve the performance of aerosols, change how particles stick together, and reduce the contact area of lactose. Neosilin is employed to enhance the flow properties and desiccate the powder for producing proniosomes.