Acne vulgaris is a common skin condition seen in adolescence that can persist into adulthood. Although treatable, it can cause immense psychological and emotional distress to patients. Rational use of topical and systemic agents can enhance therapeutic benefits and decrease adverse effects. Prescription analysis helps in understanding drug usage trends to provide suitable feedback to practitioners. The objective was to study prescription patterns in acne vulgaris. A prospective observational study was done for 9 months. Prescriptions were collected from the Dermatology OPD of a tertiary care teaching hospital, and the data was analysed using descriptive statistics. A total of 100 prescriptions were analysed. The average age of patients was 28 years and females outnumbered males . Most patients had Grade II acne (50 cases), followed by Grade I(25cases), Grade III (22cases) and Grade IV (3cases). The total number of drugs prescribed was 240, with an average of 2.4 per prescription. 204 drugs were topical preparations, and 36 drugs were given for systemic use. Retinoids, given singly, or in combination, were the most commonly prescribed topical drugs (27% of topical drugs).Doxycycline was the most frequently prescribed oral antibiotic. Only 1 patient was given oral isotretinoin.37% of the drugs were given as fixed dose combinations, the most common was adapalene+clindamycin ( 23%), followed by azelaic acid +benzoyl peroxide (7.8%).Rational prescribing is crucial to optimizing acne vulgaris treatment outcomes and our study showed rational and judicious use of drugs for acne management.