Nomophobia, or the fear of being without a mobile phone, is increasingly prevalent among adolescents. Kolcaba's Comfort Theory, which emphasizes physical, psychospiritual, sociocultural, and environmental comfort, provides a comprehensive framework for evaluating therapeutic interventions. This review synthesizes current research on nomophobia, highlights various therapeutic interventions, and evaluates their alignment with Kolcaba’s Comfort Theory to offer insights into enhancing adolescent mental health.