Background: Open wound management, despite various advancements still poses a difficult therapeutic challenge. With increased morbidity and prolonged hospital stay, the financial burden incurred by such patient’s causes significant emotional strain on the family and relatives. Negative pressure wound dressing (NPWD) with its benefits has revolutionized wound care management, but its high cost, availability and procurement in our country poses a significant challenge to an already financially weak patient. Our study was carried out to determine the efficacy and cost effectiveness of our indigenous NPWD using easily available local materials. Material and methods: A prospective interventional study was carried out on 20 patients in our institution who met the inclusion criteria. All patients’ wounds were thoroughly debrided and serial applications of our indigenous NPWD was applied and their results were studied. Results: Study group included 13 males and 7 females. 25 % of wounds were caused due to trauma. Number of dressings required ranged from 2-7 with an average of 3 .45 dressing before wound closure with a mean duration of NPWD applied for 9.5 days. The mean wound size prior to NPWD was 24.75 which significantly reduced to 19.35(p=0.027). The mean wound bed score at baseline was 9.5 which significantly improved to 13.5 at the end of 30 days. (p=0.012) The duration of hospital stay ranged from 10- 30 days with an average duration of 14.64 days. Wound closure was achieved by split thickness skin graft and secondary suturing once healthy granulation tissue was seen. Skin maceration was seen in 3 wounds for which reapplication of NPWD were delayed by 2-3 days. The average cost of each NPWD was approximately 350- 400 INR for our patients. Conclusions: Our study indicates that our indigenous NPWD is an easy to apply and economical construct, utilizing locally easily available resources, providing at par and comparable results to commercially available NPWD with good patient compliance and significant reduction in his financial burden in all strata of patients in the Indian scenario.