This review aims to provide an extensive overview of the methodologies employed in the formulation and development of cocrystals. Cocrystals, crystalline materials consisting of two or more distinct molecular entities held together by non-covalent bonds, have garnered significant attention in the pharmaceutical and materials science sectors due to their potential to enhance the physicochemical properties of active pharmaceutical ingredients (APIs). Pharmaceutical cocrystals are multicomponent systems in which at least one component is an active pharmaceutical ingredient and the others are pharmaceutically acceptable ingredients. A novel and promising method of enhancing the solubility, stability, pharmacokinetics, and dissolving profile of pharmaceuticals is co crystallization of the medicinal ingredient with a coformer.