Since olden times, humans have used plants as a natural source of treatments and therapies. Herbal remedies are popular due to their widespread applications and low risk of side effects. Currently, it is clear that there is a growing emphasis on plant research, and an enormous amount of evidence has been gathered to indicate the immense potential of medicinal plants used in various traditional systems. Every major ancient civilization in the globe has its own traditional methods for treating mental and physical illnesses. Cissus quadrangularis extract is one such natural remedy that is popular throughout the Indian subcontinent. It is a succulent herbaceous plant and belongs to the member of the Vitaceae family. It is commonly seen in the hottest parts of India, and is widely known as "Hadjod" in India, which is used to strengthen bones. Its roots and stems are particularly useful in repairing bone fractures. Bone fractures are a serious public health concern and a large financial burden worldwide, particularly among people with osteoporosis. Interesting pharmacological and nutritional properties found in the stem of Cissus quadrangularis support the maintenance of bone health. Cissus quadrangularis powder and extracts have long been used as an anabolic and analgesic, to cure infections, stimulate bone and tissue recovery, and aid in weight loss and management. The use of Cissus as an anti-osteoporotic and to improve bone fracture recovery has been validated by both animal and in vitro experiments. Cissus quadrangularis is also widely used in traditional medicinal systems for its antibacterial, antifungal, antioxidant, anthelmintic, anti-hemorrhoidal, and analgesic activities. This extract has already been used to create and analyze several dosage forms; however, the most difficult challenge is identifying which dosage forms are stable, effective, and acceptable to patients.