Introduction: School-age children (4-18 years) comprise approximately 30% of India's population, pivotal as future parents needing health education. Common health issues like sore throat, colds, bronchiolitis, infections, conjunctivitis, and pinworms are prevalent. Improved hygiene and health data from schools are essential for their well-being. Methodology: The study aims to assess anthropometric measurements, vital parameters, nutritional status, and systemic health issues in school-going children. Adopting a quantitative approach with a non-experimental design, it targets children aged 4-16 years from Angel English Medium School, Wadiwarhe. Convenient sampling technique was used to select the sample of 186 students. Data collection includes demographics, anthropometrics, vital signs, nutritional and growth status, and systemic health assessments to determine the prevalence of common health problems among the sample. Result: The systemic assessment of 186 school-going children revealed significant health findings across various categories. Skin issues like rashes affected 1.61%, with 1.08% reporting itching. No head or eye issues were observed. Ear health showed 0.54% with ear pain and 26.34% with ear discharge. Nasal discharge was noted in 17.20% of children. Dental caries prevalence was concerning at 60.75%, with one child having a mouth ulcer (0.54%) and 1.08% reporting sore throats. Normal vital signs were predominant: 86% had normal pulse rates, 96% normal respiration, and 87% normal blood pressure. Nutritional status indicated 73% were wellnourished, and 81% showed good growth and development. Fewer children had health concerns: 1.6% had skin rashes, 26% ear discharge, and 17% nasal discharge. Dental caries affected 61%, while mouth ulcers and sore throats were less common. These findings offer insights into children's health profiles, suggesting areas needing targeted interventions or monitoring to ensure continued well-being. Conclusion: In conclusion, the systemic assessment highlights prevalent health issues among school children, emphasizing the need for regular health monitoring and targeted interventions to support their overall well-being and development.