An estimated 9.0 million cases and 1.5 million fatalities from tuberculosis were reported in the 2014 global report on the disease. Multidrug-resistant (MDR) and extensively drug-resistant bacteria tuberculosis (TB) have enhanced the significance of TB control efforts for public health. The objectives stated such 1. To assess the existing level of knowledge regarding the prevention and management of side effects of DOTS therapy. 2. To assess the post-test knowledge regarding prevention and management of side effects of DOTS therapy after administration of planned teaching. 3. To compare the pretest and post-test knowledge among patients attending TB centres. Material and methods- A Quantitative Research approach and Pre-Experimental-One group- pre-test -post-test design was adopted for the study. The conceptual framework used in the study was an open system by Ludwig Von Bertalanffy’s. The study was conducted in selected DOTS centres of Sangli, Miraj Kupwad corporation. The sample size was obtained by power analysis and the Non-Probability- Incidental sampling technique was used with a sample size of 65 patients. Data collection was done by using Demographic variables and a structured knowledge questionnaire. Result And Conclusion- The pre-test revealed that the majority of patients receiving DOTS therapy 49(75.39%) had poor knowledge (Score 06-09), 10(15.38%) had average knowledge (Score 10-13), and 6(9.23%) had good knowledge (Score 14-17) scores. The post-test revealed that the majority of patients 51(78.47%) had average knowledge (Score 10-13), 10(15.38%) had poor knowledge (Score 06-09), and 4(6.15%) had good knowledge (Score 14-17) score. The calculated paired t -value is 17.2485, and the p-value is <.00001. This value is less than 0.05 level of significance. The study concluded that planned teaching regarding the prevention and management of side effects of DOTS therapy was effective.