Acalyphaindica, a plant with a rich history in Ayurveda and Siddha, is attracting interest for its potential to treat various health problems. This review explores its chemical makeup, pharmacological effects, and potential therapeutic uses. Researchers have identified promising bioactive compounds like tannins and flavonoids within the plant. Extracts and isolated compounds show a range of benefits including wound healing, anti-asthma effects, and even antivenom activity. Recent studies reveal Acalyphaindica potential as a multifaceted therapeutic agent with anti-inflammatory, antibacterial, antioxidant, and even anti-diabetic properties. These findings not only validate its traditional uses but also suggest new applications like treating coughs (expectorant), fluid retention (diuretic), and worm infections (anthelmintic). Overall, this review adds valuable knowledge about Acalyphaindica, solidifying its position as a powerful medicinal plant with diverse therapeutic possibilities.