ABSTRACT Aim: Dengue is a chief health crisis also one of main common vector transmitted viral infection globally. Numerous factor have been ascribed to augmented illness and death with distorted hematological and coagulation factors having more influence. The current work was done to investigate the hematological indices and associate with the clinical outcome, also to assess the importance and requirement of platelet transfusion and its outcome. Methodology: 50 patients admitted in Department of general medicine, in association with department of pathology, Saveetha Medical College, Thandalam, Chennai with fever and serological positive cases were included. Statistical analysis was done for the various parameters as per requirement Using SPSS software. Results: Among fifty patients included in our study, almost all patients presented with fever and headache .Myalgia, was one another common presenting complaint. Leukopenia identified in 70% of patients. , NLR ratio was reversed in 28% of patients. Platelet transfusion was required in 42 patients. Mostly patients took 3 days to recover after platelet transfusion. Conclusion: As per our study presence of fever with headache, NLR ratio reversal, decreased platelet count and WBC count. Also clinical features related to capillary leak and increase in hematocrit should always give us solid thought of dengue fever. Platelet transfusion in patients diagnosed with moderate to severe thrombocytopenia demonstrated to be beneficial for suave rescue of the patient