This study investigated the effects of aqueous stem bark of Cissus populnea (C.p) extract on some parameters in diabetic Wistar rats. Fresh stem bark of C.p was air dried, pulverized, and mixed with distilled water at room temperature for 72 h; then flittered (11 m) and the dried filtrate (C.p extract) was used for the animals treatment, which was in 5 groups of 6 rats each: Group 1: normal control, Group 2: treated with 200 mg/kg body weight (b.w) of C.p extract; Group 3: treated with 500 mg/kg b.w of C.p extract, Group 4: treated with 100 mg/kg b.w metformin, while Group 5 untreated, after groups 2-5 were induced with diabetes mellitus with alloxan, the study was for 21 days.