Proparacaine belongs to the group of medicines called local anesthetics. It belongs to the BCS class II, which are poorly water soluble. Proparacaine was first synthesized by Apothecon BV. It is found in ophthalmic solutions at a concentration of 0.5% as the hydrochloride salt. The exact mechanism whereby proparacaine and other local anesthetics influence the permeability of the cell membrane is unknown; however several studies indicate that local anesthetics may limit sodium ion permeability through the lipid layer of the nerve cell membrane. Proparacaine may alter epithelial sodium channels through interaction with channel protein residues. Examining the several analytical estimates of proparacaine and comparing it to other drug compounds is the main objective of this review. This is a comprehensive summary of earlier research on the drug proparacaine.