Aim: Medicinal plants can effectively lower the oxidative stress that causes diabetes mellitus. This study investigated the potential benefits of Diapensia himalaica Methanolic Extract (DHME) for the treatment of diabetes. The study evaluated the antihyperglycemic activity of DHME in both normal off-feed animals and glucose-loaded animals with diabetes, supporting its anti-diabetic effects. Additionally, the chronic multiple dosage therapy lasting twenty-eight days examined DHME's confirmed antidiabetic effectiveness and its role in ameliorating toxicity. Material andMethods: The study utilized a single dose of alloxan (120 mg/kg) to induce hyperglycemia, leading to elevated levels of total lipids, triglycerides, and cholesterol, along with reduced insulin levels. The investigation aimed to determine the effectiveness of DHME in alleviating these diabetic symptoms. Results: