ISSN : 2663-2187

AN APPROACH TOWARDS GREEN ANALYTICAL CHEMISTRY: SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF CELECOXIB IN CAPSULE FORMULATIONS

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Km. Saiphali, Alankar Shrivastava, Neha, Jyoti Gwasikoti, Anil Kumar, Abhishek Sharma, Kapil kumar, Gaurav Agarwal
» doi: 10.33472/AFJBS.6.9.2024.1197-1212

Abstract

Celecoxib (CXB) is a NSAIDs or nonsteroidal anti-inflammatory drug pre-owned in the therapy of knee pain and body inflammation, correlated with inflammatory disorders, and assorted other rheumatoid arthritis. The unprejudiced of this education was to expand an uncomplicated, high diplomatic, selective, and fast quantitative analytical and bioanalytical procedure for evaluation of Celecoxib drug as API. The drug manifest absorption maxima at 253nm. A new uncomplicated, precise, diplomatic, highly certain and economical ultraviolet spectrophotometric (UV) method for the analysis of celecoxib drug in mass or bulk and its pharmaceutical expression or formulation (capsules) has been expended. The absorbance sample of celecoxib in a combination of methanol and 0.1 N sodium hydroxide (1 :1 v/v) were expended or set on at 253 nm. Reducing the usage of solvents is aim in development of green analytical method. Beer's law is bow to above concentration range of 1-13 μg/ml with correlation coefficient r2>0.998. The conclusions have been verified mathematically and by recovery studies. Method was flourishing employed for the analysis of celecoxib drug in the existence of the expression or formulation, and analytically compared between the suggested procedures. Therefore, the suggested methods can be employed for routine quality control (QC) studies

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