Molecular docking is an emerging field that can aid in tackling rising environmental issues such as microplastic (MP) pollution. MP poses a threat to both the environment and human health, which makes its degradation crucial. Biodegradation is the most efficient eco- friendly method that uses the ability of microbes to secrete enzymes that can break down polymers. However, the in vitro culturing of microorganisms and screening of efficient enzymes in biodegradation is laborious and time-consuming.