Background: Though it can save lives, mechanical ventilation (MV) has the potential to cause diaphragmatic dysfunction (DD) and myotrauma, which are injuries to the muscles of the diaphragm. Prolonged ventilation, weaning failures, and death are some of the worst negative effects linked to DD, which is why it is important to address. The main causes of myotrauma are patient-ventilator asynchrony (PVA) and insufficient mechanical ventilation (MV) support in responding to the patient's respiratory effort (over- or under-assistance). Myotrauma prevention techniques, such as MV with diaphragm protection, were developed in response to the recognition of these mechanisms. These treatments primarily center on titrating suitable degrees of inspiratory effort to minimize PVA and over- or under-assistance. In order to keep the diaphragm safe during MV, instruments that measure diaphragmatic effort and identify PVA are necessary. One non-invasive method for monitoring diaphragmatic function, evaluating PVA, and maybe even defining diaphragmatic effort with protected breathing is diaphragm ultrasonography. The purpose of this review is to give doctors a synopsis of DD's importance, the key mechanisms that cause myotrauma, and the most up-to-date methods for reducing myotrauma, with a focus on the use of ultrasound to monitor diaphragm function and its role in in the Assessment of Weaning from Mechanical ventilation.