ISSN : 2663-2187

An Overview about Trichinosis; Morphology, Pathogenesis and Presentation

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Esraa Saleh Ibrahim Mousa, Alaa M. Elgendy, Sabah M. A.Mohamed, Howayda S.F. Moawad
ยป doi: 10.33472/AFJBS.6.2.2024.911-917

Abstract

Trichinosis is a re-emerging zoonotic disease that has develops a public health concern since its reported human outbreaks in many countries. Both male and female are colorless. The cuticle is smooth, but shows pseudo segmentation and is disturbed by dorsal and ventral pairs of hypodermal gland cells. The somatic musculature consists of a single layer of muscle cells. Muscle cells contain mitochondria, prominent contractile filaments and a large nucleus. The alimentary tract involves an oral cavity, capillary oesophagus, midgut with brush border and hind gut. An inflammatory response is prompted at the intestinal level in the host, playing a crucial role in the expulsion and elimination of the parasite during the course of infection with T. spiralis. However, many studies have proved that this inflammatory response is harmful to the host. Through the enteral phase of the infection, the existence of the adult and larvae in the mucosal and submucosal layers causes an inflammatory response and functional changes in the motility of small intestine. Obviously, light infection causes slight damage but, with more severe infections, hyperemia, petechiae of the serosa, excessive mucous secretion, enlarged Peyer's patches and dilatation of loops of bowel occur. Histopathology of the small intestine shows that there is strong inflammatory response with mixed cellular infiltration mainly neutrophils, eosinophils and lymphocytes in the jejunum. The onset of symptoms can range from 12 hours and two days after ingestion of infected meat. Movement of worms in the intestinal epithelium can cause severe damage to the host tissue and the waste products they excrete can provoke an immunological reaction. 5-7 days after the presence of symptoms, facial edema and fever may occur. After 10 days, weakening of pulse, blood pressure, intense muscular pain, difficulty in breathing, heart damage and various nervous disorders may occur, eventually leading to death due to heart failure, respiratory complications or kidney malfunction. Low-intensity infection can remain asymptomatic.

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