Mucoadhesive buccal drug delivery devices have attracted a lot of interest as a viable strategy for delivering medications through the mouth cavity. Due to its potential to address a number of concerns with conventional oral drug administration, including low bioavailability, first-pass metabolism, and patient compliance issues, this delivery strategy is of considerable interest. The mucosal membranes in the oral cavity are targeted by Mucoadhesive formulations, which offer an effective path for medication absorption. This abstract explores the main features, benefits, and uses of Mucoadhesive buccal drug delivery devices. The buccal mucosa, which is covered with blood vessels and provides a moderately permeable barrier to medication absorption, is utilized by these systems for its special qualities. Additionally, this method is quite practical for patients since it is simple to reach the oral cavity. In order to provide prolonged drug release and better drug bioavailability, mucoadhesive buccal drug delivery systems require the selection of appropriate polymers and excipients that can stick to the buccal mucosa. These formulations' Mucoadhesive qualities lengthen the period that the medicine is in contact with the mucosal surface, which encourages effective drug absorption. Controlled drug release, less changes in drug levels, and the possibility to prevent the hepatic first-pass impact are benefits of Mucoadhesive buccal drug delivery systems. Furthermore, they are adaptable for a range of therapeutic applications since they may be employed for both systemic and local drug administration. The expanding significance of Mucoadhesive buccal drug delivery systems as a technique of delivering medications through the mouth cavity is highlighted in this abstract. The focus of this field's study is currently on improving formulation methods and investigating cutting-edge medication delivery systems. These developments have the potential to revolutionize the pharmaceutical industry by providing patients with more practical, efficient, and patient-friendly medication delivery options.