The spread of African Swine Fever (ASF), a highly contagious virus affecting pigs. ASF emerged in Indonesia in 2019, leading to significant pig mortality. The disease was detected in wild boars in a Way Kambas National Park (WKNP), prompting investigations. Organ samples (spleen, bone marrow, liver, and lung) were collected from both bodies and tested for ASF using polymerase chain reaction (PCR). All organ samples tested positive for ASF. Concurrently, in domestic pigs, 27 ASF outbreaks were reported in South Lampung and 2 outbreaks in East Lampung. The outbreaks in East Lampung occurred in Braja Selebah, a buffer area for WKNP, and killed nearly 1000 pigs. The study explored the link between wild boar mortality and domestic pig outbreaks, finding evidence of ASF transmission. Poor farm biosecurity and waste management likely contributed to the spread via contaminated rivers. Authorities responded by educating communities, disinfecting farms, and involving various groups for swift case detection. The study confirms that ASF caused wild boar deaths and highlights the interface between domestic pigs and wild boars as a transmission route. Multisectoral measures were implemented to mitigate ASF risks from farms and enhance rapid response capabilities.