The Andrographis paniculata plant produces andrographolide, a labdane diterpenoid that has a wide range of therapeutic uses. However, because of its low skin penetration and limited water solubility, andrographolide transdermal distribution and performance face significant challenges. Invasomes containing andrographolide were created utilizing a perfunctory dispersal procedure. Invasomes were identified and improved in expressions of skin retention studies, vesicle size, ex vivo permeability, entrapment efficiency, and in vitro drug release. The ideal invasomal formulation was turned into a topical gel. The Higuchi kinetic model for release was strongly supported by the invasomal gel in vitro release studies. The invasomal gel's andrographolide penetration through the skin of the pig's ear was 2.5 times greater and had a flow of 155.020.12g/cm2/h, according to an ex vivo research. According to the study's findings, invasomes have a high potential for delivering andrographolide transdermally, which could increase andrographolide's topical utility in a variety of skin disorders.