ISSN : 2663-2187

ANTI UROLITHIATIC HERBAL FORMULATION: DEVELOPMENT, STANDARDISATION AND EVALUATION

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Ujjwal Chaudhary, Mr. Obed Singh, Dr. Shivanand Patil
ยป doi: 10.48047/AFJBS.6.12.2024.3536-3553

Abstract

Urolithiasis, also known as kidney stones, is a medical condition affecting around 10% of the global population and is more common in men. Treatment strategies include lifestyle and dietary changes to lower risk factors and the possibility of recurrence. Bryophyllumpinnatum, also known as the "miracle leaf" or "life plant," is rich in bioactive substances such as flavon oids, tannins, glycosides, steroids, alkaloids, triterpenes, and phenolic compounds. These compounds contribute to the plant's anti inflammatory, antibacterial, antioxidant, analgesic, and possibly anti cancer properties.Conventional therapies for urolithi asis often have drawbacks, such as invasiveness, inadequate therapy, and restricted accessibility. This research focuses on developing an anti urolithiatic herbal formulation using medicinal plants and aiming to produce a strong, standardized formulation t hat may improve urolithiasis therapy and improve patient outcomes. The study studied the pharmacological effects of herbal medicine extracts from Bryophyllumpinnatum and Bergenia ciliata, using various sources and instruments.The research established stand ard calibration curves for Bryophyllumpinnatumin and Bergenia ciliata extracts in 6.8 pH phosphate buffer, conducted anti urolithiatic activity tests, and established the optimum dissolving efficiency of calcium oxalate crystals in various groups. The herb al capsules were produced and tested for color, shape, size, acceptability criteria, disintegration time, and stability.Over 60 days, the capsules retained their physical qualities and dissolving characteristics, indicating their potential for application in urolithiasis treatment. Overall, these findings demonstrate the viability of employing Bryophyllumpinnatum and Bergenia ciliata extracts in pharmaceutical formulations targeted at treating urolithiasis efficiently.

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