Typhoid fever is caused by Salmonella Sp. and is acquired by ingestion of food or water contaminated by faeces of infected humans or person-to-person contact. It has become more difficult to treat as the antibiotics used to treat them have become less effective, as well as having harmful side effects. Aim: To search for natural antimicrobial agents in the nature which are harmless and can be used to make drugs with natural ingredients replacing synthetic. Methodology: Some fruits were picked from farm and fresh juice was extracted which were tested against Salmonella typhi using agar well diffusion method. Results: Kokum and Papaya were seen to have very good inhibitory effect on Salmonella typhi with zone sizes of 34 mm and 30 mm respectively. Pineapple could inhibit S. typhi with 16 mm zone size whereas; Cashew did not show any activity against Salmonella typhi. Conclusion: These fruits can be used in making natural antibiotics or antibiotics free from any synthetic or chemical substances against Typhoid Fever and Salmonellosis