The Streblus asper Lour belonging to the family Moraceae is very popular in countries like India, Philippines, Malaysia, Thailand. It is a well-known ethnomedicine amongst the local tribes and communities of these countries. It is known for its promising antimicrobial, antiplaque, antihyperlipidemic, antioxidant, antidiabetic, anti-inflammatory, antipyretic properties. This study shows the evidence of promising actions based on the outcomes of the antimicrobial screening and antioxidant study performed using the extract. The physicochemical tests have been performed and the extensive phytochemical screening shows the presence of different metabolites in it. In the antimicrobial study the hydroalcoholic extract was found effective towards E coli and Staphylococcus aureus. The results of the study validate the traditional belief on the plant.