The study aims to evaluate and compare the withdrawal symptoms and triggering factors experienced by users of smoking and smokeless tobacco products. Tobacco addiction remains a significant public health concern, with both smoking and smokeless tobacco use leading to substantial health risks. Understanding the withdrawal symptoms and triggers that affect users is crucial for developing effective cessation strategies. This review analyzes data from various clinical studies and surveys to identify common and unique withdrawal symptoms between smoking and smokeless tobacco users. Key withdrawal symptoms include irritability, anxiety, difficulty concentrating, and cravings while triggering factors encompass stress, social situations, and habitual routines. The comparison highlights similarities, such as nicotine dependence, and differences, such as the intensity and duration of withdrawal symptoms. Smokeless tobacco users often report more localized oral discomfort, whereas smokers experience more respiratory-related issues. The findings underscore the need for tailored cessation programs that address the specific withdrawal symptoms and triggers of each user group. Enhanced understanding of these factors can lead to more personalized and effective interventions, ultimately reducing the health burden associated with tobacco use.