The Kon River plays an important role in the basin, providing water and drainage for people's livelihood activities, being a waterway for boats to travel up and down, being an aquatic ecological environment favored by many aquatic species,... This study statistics and evaluates the impact of waste sources on the water quality of Kon River by water sample collecting and analyzing. Water samples from 11 sites in surface water layer of Kon River and 16 sites at wastewater sources were collected and analyzed parameters of water quality. The analyzed results show that at the beginning of the study river section - T1 site - Tay Giang village, the water quality was quite good, to meet the limit values of level A of QCVN 08:2023/BTNMT - good water quality. But from T2 site to downstream, the water quality of Kon River degrades gradually, at several study sites such as T3, T4 , water quality only meets the limit values of level B of QCVN 08:2023/BTNMT while at other study sites such as T5, T8, T9, T10, water quality meets the limit values of level D of QCVN 08:2023/BTNMT. This deterioration of water quality is due to receiving domestic, livestock, craft village,... wastewater from residential areas in the basin discharge to Dong Pho River, Dong Tre River, Ham Ho River, public sewers,... then discharged into the Kon River. This proves the deterioration of water quality in the studied river section due to the river section flow through a densely populated area with strong economic and social activities in livestock, production, services, ... without good management of wastewater discharge. Proposing solutions to protect and improve water quality of Kon River it is necessary to have a good managemental policy with each type of wastewater, especially livestock wastewater, domestic wastewater and noodle-making village wastewater