This research was designed to assess the nasopalatine canal shape, size as well as anatomic variations according to age & gender in a sample of the Egyptian population utilising CBCT . Material and Methods: This research was conducted on 100 CBCT scans belonging to 31 males & 69 women, with mean age of (35.8 ± 12.3) years. Inclusion and exclusion criteria as well as ethical issues were designed. CBCT scans were classified according to gender (male and female) and according to age (18-40 year and 41-61 year). All nasopalatine canals were evaluated to assess nasopalatine canal shape in coronal view and sagittal view as well as measurements of the nasopalatine canal in the sagittal & axial cross-section CBCT. The data were collected, computed, tabulated and statistically analyzed. Results: Was observed no statistically substantial association amongst gender & NPC shape. Also, was noted no statistically substantial association amongst age group and NPC shape. Males showed statistically significantly higher mean diameter of incisive foramen and nasopalatine canal length than females. Subjects aged 18 – 40 years old showed statistically significantly lower mean antero-posterior diameter of nasal foramen, medio-lateral diameter of incisive foramen as well as canal diameter than those aged 41 – 61 years old. Conclusions: The most frequent NPC shape in coronal view is variation of the Y-type of NPC in half of participants followed by single canal and the least was 2 parallel canals. The most frequent NPC shape in sagittal view is funnel shape (29%) followed by cylindrical shape (28%). The antero-posterior diameter of the incisive foramen & the nasopalatine canal length are higher in men than women. The antero-posterior diameter of the nasal foramen, the medio-lateral diameter of the IF and the NPC increase with aging