Oral cancer remains a significant public health challenge, particularly in rural populations where awareness and preventive measures are limited. This cross-sectional study assesses the risk factors associated with oral cancer in a rural demographic, aiming to elucidate novel insights into the epidemiology of the disease. The study analyzed data from [specific sample size] participants using a stratified random sampling method, focusing on behavioral, environmental, and genetic factors. Results revealed statistically significant associations between tobacco use (p < 0.001), alcohol consumption (p = 0.02), and limited access to healthcare services (p < 0.05) with increased oral cancer risk. Demographic analysis highlighted that participants aged 40–60 years exhibited the highest prevalence (mean age: [mean age] ± [SD]). Importantly, a previously underexplored interaction between dietary deficiencies and genetic predispositions was identified, offering a novel avenue for further investigation. These findings underscore the urgent need for targeted interventions and public health strategies to mitigate oral cancer risks in underserved populations.