Background: Type 2 diabetes mellitus (T2DM), chronic metabolic disorder and its prevalence is raising globally. The micro and macrovascular complications in T2DM increases with duration of disease and prevailing of chronic hyperglycemia. Adenosine deaminase, a key regulating enzyme of adenosine levels and concerned with cell mediated immunity. ADA gives a promising result as a common marker for glycemic control, insulin resistance and pathogenesis of disease. The present study was undertaken to evaluate association of insulin resistance with adenosine deaminase levels in type 2 diabetes mellitus and their correlation with liver enzymes.