Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting women of reproductive age. Women with PCOS are at a higher risk of developing hypothyroidism. Studies have shown that women with PCOS have a higher prevalence of elevated TSH levels, suggesting an association between these two conditions. The hormonal imbalances associated with PCOS may lead to changes in the thyroid gland function, causing changes in the TSH levels. Early detection of hypothyroidism in women with PCOS is important, as it can lead to improved management and treatment of both conditions. Aim and Objectives: The present case control study was conducted to evaluate Thyroid profile, Endocrine parameters and BMI in PCOS patients and control subjects and find out the correlations between these parameters. Methods: In this case-control study, total 209 subjects were included 104 cases and 105 controls aged between 20- 40 years. Cases were diagnosed PCOS women and controls were apparently healthy subjects. The Rotterdam criteria were used to diagnose PCOS in women between the ages of 20 and 40 years who had no other known causes of irregular menstruation. Biochemical parameters such as thyroid stimulating hormone (TSH), Triiodothyronine (T3), Thyroxine (T4), Luteinizing hormone (LH), and Follicle stimulating Hormone (FSH) were estimated by using commercially available ELISA kit and BMI were measured. Results: The mean of age for both case and control were 25.47±4.40 and 26.49±4.54. Serum LH and TSH levels were found to be significantly increased (4.73±1.504: 4.21±1.5), (3.31±0.89: 2.23±0.80) with a p value 0.0164 and 0.0001 respectively. T3 and T4 values were decreased (1.59±0.04: 2.23 ±0.46), (89.94±8.66: 92.44±9.12) with p value 0.0001 and 0.0431 respectively. BMI (23.73±3.20: 23.83±3.78) with p value 0.8363. FSH (4.040±1.44: 4.68 ±1.59) with p value 0.0026. Conclusion: Patients with Polycystic Ovary Syndrome (PCOS) have a higher subclinical hypothyroidism prevalence than healthy individuals according to the study. This finding underscores a possible relationship between PCOS and thyroid dysfunction. Further research and clinical evaluation are needed so as to comprehend the underlying mechanisms and implications of such an association.