This study looks back at a 19-year-old female patient who tested positive for HIV. The subject's parents are HIV positive, and mother to child vertical transmission is the mode of transfer. When she was three years old, her mother passed away. At three years old, the subject was placed in an orphanage. She wants to become adept at coexisting with her father. No previous experience in psychiatry. Not getting enough sleep Taking care of oneself, being functioning, bleeding nose, and hunger. Suspicion, continuous depression, hearing voices, thoughts of suicide. She is on ART with the combination of TLD regimen. She started taking antiretroviral therapy (ART) in 2008 with the combination of ZLN regimen.The incidence of these neurocognitive disorders is augmented among People Living with HIV (PLWH); the physical ramifications of stress increase the likelihood of HIV acquisition, pathogenesis, and treatment, as both stress and HIV infection are characterised by chronic inflammation, which creates a more opportunistic environment for HIV. The impact of chronic stress exposure and the origin of individual variation in stress responses and resilience are at least in part attributable to regions outside the primary stress circuitry, including the amygdala, prefrontal cortex, and hippocampus.