Obesity is a condition characterised by the excessive or abnormal deposition of fat or adipose tissue in the body which leads to complicated health issues connected with several harmful impacts on well-being, including an increased risk of various medical diseases and considerable cost burdens on healthcare systems and society. This study analyses the Ayurvedic concepts of Staulya and Medho Sara about Metabolically Healthy Obesity (MHO) and Metabolically Unhealthy Obesity (MUO). Medho Sara, characterized by excellence in adipose tissue, correlates closely with the notion of MHO, where persons with obesity do not exhibit conventional cardiometabolic concerns. In contrast, Staulya, indicating pathological obesity, correlates more with MUO, defined by metabolic abnormalities and elevated risks of type 2 diabetes and cardiovascular illnesses. The research intends to illustrate how comprehending Medho Sara and Staulya can aid in the early identification of high-risk patients for metabolic imbalances and cardiovascular illnesses. By merging traditional Ayurvedic wisdom with modern medical viewpoints, this study hopes to bring fresh insights into the holistic management of obesity. Clinical and laboratory examinations were undertaken on individuals with obesity to differentiate between Medho Sara and Staulya phenotypes based on numerous factors such as BMI, blood pressure, glucose levels, lipid profiles, and markers of insulin resistance. The data demonstrated a prevalence of 30.1% for the Medho Sara phenotype among people with obesity, showing major disparities in clinical and biochemical parameters between the two phenotypes. Medho Sara residents were considerably younger, had lower BMI and waist circumference compared to Staulya individuals. Additionally, biomarkers associated with insulin resistance differed considerably across the two groups, with higher adiponectin levels in Medho Sara and lower uric acid levels compared to Staulya. This study adds unique insights into the varied metabolic profiles within obesity via the lens of Ayurvedic principles, underlining the significance of tailored approaches for controlling obesity-related illnesses based on specific phenotypic traits. The merging of ancient knowledge with modern scientific understanding offers a viable option for furthering obesity research and improving individual health outcomes