Rheumatoid Arthritis is one of the most widespread illnesses, which can affect millions of people and significantly limits their everyday activities. Patients who are suffering may exhibit a variety of clinical signs, from minor symptoms like mild discomfort, swelling, joint immobility, muscle atrophy. A person with severe arthritis is incapable of performing daily tasks, including walking and moving around. It may result in ligament deterioration and structural damage to joints over time. 180 million Indians, or about 15% of the population, suffer from rheumatoid arthritis. In rheumatoid arthritis, the immune system of the host attacks its own cells, causing joint swelling and immobility as well as widespread bone and damage cartilage in the joints. Due to formation of oxygen free radicals from O2 metabolism leads increase in reactive oxygen species (ROS) which play significant roles in the pathophysiology of RA. The NF-kB pathway stimulation causes cells to release pro- inflammatory mediators as IL-1, TNF-α, and chemokines. Clinically, the major RA treatments are non-steroidal anti-inflammatory medicines (NSAIDs), disease modifying anti- rheumatic medications (DMARDs), and glucocorticoids they relieve RA patients' by reducing synovitis and systemic inflammation. Phytoconstituents have ability for treating rheumatoid arthritis by converting them into nanoparticles. Researchers are concentrating on natural compounds to generate novel anti-inflammatory medicines, despite the fact that numerous steroidal and NSAIDs have been created.