Epilepsy was one of the most frequent severe brain diseases. It can affect people of all ages and has a wide range of symptoms and causes. Anti seizure drugs (ASDs) were potentially an effective treatment for epileptic patients. However, treatment failure and poor adherence were very common in patients experiencing side-effects due to ASDs. In approximately 25% of patients, side-effects of ASDs lead to treatment discontinuation and negative impact on the quality of life. Tapering or discontinuation is considered an important step in controlled epileptic patients with long term use of anti-epileptic drugs after they are seizure‐free for period of 2 years or more because of compelling complications like adverse drug effects, cost of treatment, and social stigma. In recent decades, many studies have focused on the risk of seizure recurrence after ASD withdrawal, which varies from 12% to 67%.