Objective: This paper aims to to explore the evidence of the association between dental caries experience in individuals and different "Big-Five" personality traits. Method: A systematic review of literature was carried out d to identify articles reporting a relationship between dental caries experience and personality traits. An electronic search was performed on the databases of PubMed, Google Scholar, Science Direct, Cochrane Library and Scopus. The keywords used were: “high health risk”, “personality traits” “neuroticism”, “experience high stress” “experience low stress”, “agreeableness”, “conscientiousness”, “extraversion”, “introversion” “Eysenck” “questionnaire”, “DMFT”, “DMF” “dental caries”, “oral health”. After eliminating the duplicate articles, the studies were screened for eligibility by two independent investigators to identify “potentially eligible” studies and the disagreements were resolved by consensus after discussion. The inter-reliability score was assessed by Cohen’s Kappa (0.00943). Results: Six studies were included in the review, most of which were cross-sectional in nature. Neuroticism showed a positive correlation with dental caries in four out of the six studies. Conclusion: Individuals with higher neuroticism traits tend to experience increased dental caries prevalence experience. The evidence obtained from this systematic review emphasizes the need for further well-designed, randomized, and controlled clinical trials evaluating the effect of different personality traits in the incidence of dental caries over a period few years.