Malaria is a worldwide epidemic. Nine species of Anopheles act as a carrier of Plasmodium causing malaria. Its worst scenario can be seen in many African and Asian countries. India is among one of them. In India, state of Madhya Pradesh (MP) was one of the most vulnerable states for Malaria till 2015; afterwards conditions got improved due to the special efforts made by the government, NGOs, researches, awareness programs, ICT etc. For the research work Primary data is collected by using questionnaire in order to find out, why such many out-burst and casualties due to malaria are seen in MP? What necessary measures are required to minimize the cases? Secondary data is collected from the different Government departments, websites and District Malaria Offices in order to get the trend of malaria recorded. Pre and post preventive measures taken to minimize the cases are also summarized. Data is tabulated, graphs are developed. It is found that great decrease is observed in the positivity rate and casualties from 2015 afterwards. It also came into observation is that people were aware about the Vector Borne diseases, distribution and use of ITNs, intensive implementation of National Framework for Malaria Elimination and Active participation of District malaria Officers in Madhya Pradesh, NGOs and research scholar’s contribution minimize the number of cases in Madhya Pradesh. Consequently, less than 3% malarial positive cases are remains in the year 2022 in the state MP; base year 2015