Background: Obesity is considered a multifactorial, and highly preventable disease. Laparoscopic sleeve gastrectomy (LSG) has shown considerable interest as a low morbidity bariatric surgical procedure.This work aims to assess the improvement in lipid profile andhemoglobin A1c HbA1c in obese patients with prediabetes before and after laparoscopic sleeve gastrectomy. Methods:The study comprises 37 patients, aged 18-60 years, with BMI>35, diagnosed to have prediabetes. The study assesses the changes in HbA1c and lipid profile before and 6 months after sleeve gastrectomy. Patients were recruited from bariatric outpatient clinic at Cairo university hospitals. Results:HbA1c showed significant reduction 6 months postoperatively. Also, total cholesterol, LDL and triglycerides showed significant reduction 6 months post-operatively and HDL showed significant improvement 6 months post-operatively (P value<0.001). Conclusion: There was significant reduction in post-operative HbA1c, total cholesterol, LDL and triglycerides also significant improvement in postoperative HDL. This indicates that LSG significantly decreases the risk of developing type 2 diabetes in severely obese patients. Therefore, pre-operative assessment of HbA1c, BMI, total cholesterol, LDL, HDL and triglycerides is essential as this help in identifying the patients who can benefit from LSG.