Background and Objectives: Bowel perforation is mostcommon cause of surgical emergency. Perforation of the small intestine causing peritonitis is the most common abdominal surgical emergency encountered. The objective of the study was to analyze the Clinico-Pathological Relations of Small bowel perforations to better understand the condition. Materials and Methods: This study was prospective clinicopathologicalstudystarting from March 2015 to January 2024 carried out in Dhiraj General Hospital, Vadodara in GeneralSurgery Department. 300 patients presenting with features of small bowel perforation were studied. Conclusion: Perforation commonly occurs in youngmales. Pain, abdominal distension along with Generalized tenderness was commonly found in all.Nonspecific inflammation was most common nontraumatic cause of illeal perforation after bluntabdominal trauma. Stress, smoking and NSAIDS were common risk factors involved in causation of bowelperforation