Background: With increased awareness about breast cancer, many women with breast lumps are attending clinics. Though benign breast lumps are most common, they may be associated with morbidity and have become cause for concern to patients. Triple assessment by clinical, radiological and pathological examination is a standard approach in the evaluation of breast lumps. Even in cases of benign breast diseases, multimodality tests are being preferred to give reassurance to patients. This study was aimed to study distribution of various benign breast lumps in relation to age at presentation, to identify sensitivity and specificity of clinical breast examination, Ultrasonography (USG) and Fine needle aspiration cytology (FNAC) methods in the evaluation of benign breast lumps and to compare with final histopathological diagnosis. Material and methods: This Prospective Observational Study was Conducted in Our Hospital, a 500 bedded multi- Amey Paranjape /Afr.J.Bio.Sc. 6(7) (2024) Page 2984 of 9 disciplinary hospital. This hospital has a Comprehensive cancer centre exclusive to cancer patients. Subjects who presented with symptomatology of BL or pain throughout the study duration made up the study population. Patients who visited the surgical OPD in the surgical department constitute the study population. The study involved those research participants who met the inclusion criteria. This study was conducted from December 2020–July 2022. A total of 100 patients were included out of the total female examined and who met the inclusion criteria. Results: The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of histopathological findings were found to be 98.6%, 96.4%, 99%, and 90% respectively. Clinical examination presented a sensitivity of 97.8%, specificity of 68.2%, PPV of 92%, and NPV of 93.4%. Whereas, it was 98.3%,71.4%,93.1%, and 91.5% in the USG examination. In our study there were 30% of patients who had breast complaints however on evaluation there was no BL or disease was found. During our study 2 male patients with gynecomastia were found however they did not had any BLs. Conclusion: BL and BL with pain were the most common symptom observed in subjects followed by nipple discharge, BL with nipple discharge, and nipple discharge respectively. Fibroadenoma was the most common finding in the majority of the patients followed by fibrocystic disease, phyllodes tumour, duct papilloma duct ectasia, and galactocele. Histopathological examination was significantly correlated with clinical and USG examinations. Histopathological examination is more effective in the determination of benign breast disease compared to other modalities however, a combination of clinical and USG examination could be similarly effective as histopathology. Further studies are warranted to confirm the present study findings.