This meta-analysis investigates assessing and comparing the adverse effects associated with three pivotal COVID-19 vaccines: Covishield, Covaxin, and Sputnik V. The study aims to dissect the prevalence and nature of reported adverse effects after vaccination. A comprehensive analysis was meticulouly carried out through a systematic review of varied databases encompassing PubMed, Google Scholar, and Cochrane. This thorough examination involved amalgamating data from a total of 24 works of literature, which included extensive literature and clinical trials. Various adverse event categories were examined covering Thrombotic Events (TTS), Neurological, Cardiovascular System (CVS), Ocular, Cutaneous, Musculoskeletal, Gastrointestinal Tract (GIT), Lymphatic, Shortness of breath (SOB), and Influenza like symptoms. Distinct incidence rates were unveiled, indicating notable variations among the vaccines. Covishield exhibited marked prevalence in TTS (OR: 1.1252, CI: 0.5078 - 0.5518) and CVS-related adverse effects (OR: 0.2539, CI: 0.189-0.215). Covaxin demonstrated significant occurrences in cutaneous and musculoskeletal categories (OR: 0.2707, CI: 0.186-0.240), while Sputnik V displayed increased incidences in musculoskeletal (OR: 0.7365, CI: 0.4094-0.4388), GIT (OR: 0.1157, CI: 0.097-0.110), and neurological adverse effects (OR: 0.2004, CI: 0.156-0.178). Understanding the differential risks of adverse effects among these vaccines is pivotal for informed decision-making and shaping effective public health strategies in the ongoing global vaccination endeavor, despite their generally acceptable safety profiles.