Background: The choice of anesthetic agents in neurosurgical procedures plays a crucial role in patient outcomes. This study aimed to compare the effects of Sevoflurane and Isoflurane on intra-operative hemodynamic response to stimulus, degree of brain swelling (secondary outcome), and early post-operative recovery outcomes. Methods: A prospective comparative study was conducted involving two groups: Group S (Sevoflurane) and Group I (Isoflurane). The study included 60 patients undergoing neurosurgical procedures. Hemodynamic stability was assessed by measuring heart rate, systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) at various time points, including baseline, intubation, pin insertion, incision, post-operation, closure, pin removal, extubation, and post-extubation. The emergence time, extubation time, Aldrete Score (indicative of recovery), Brain Relaxation Score (reflecting brain relaxation during the procedure), and adverse events were also recorded to evaluate postoperative outcomes. Results: Sevoflurane demonstrated significantly shorter emergence and extubation times compared to Isoflurane, indicating a faster recovery and smoother restoration of airway reflexes. Sevoflurane also resulted in a shorter time to achieve an Aldrete Score greater than 8, reflecting a quicker postoperative recovery. Both Sevoflurane and Isoflurane exhibited comparable effectiveness in achieving optimal brain relaxation, as indicated by the similar Brain Relaxation Scores. The incidence of adverse events, including nausea/vomiting and shivering, was similar between the two groups, indicating comparable tolerability. Hemodynamic analysis revealed significant differences in heart rate, SBP, DBP, and MAP between the two groups at different time points, suggesting distinct effects on hemodynamics during the procedure. Conclusion: This prospective comparative study provides evidence of the differential effects of Sevoflurane and Isoflurane on hemodynamic stability, including heart rate, SBP, DBP, and MAP, as well as postoperative outcomes in neurosurgical procedures. Sevoflurane demonstrated advantages in terms of faster recovery, smoother airway reflex restoration, and quicker postoperative recovery compared to Isoflurane. The comparable effectiveness in achieving optimal brain relaxation and similar tolerability between the two agents indicate their overall suitability for neurosurgical anesthesia. However, the observed differences in hemodynamic parameters, including MAP, emphasize the importance of individualized anesthetic management to ensure optimal patient care. Further research with larger sample sizes and long-term outcome assessments is recommended to validate these findings and explore the cost-effectiveness of Sevoflurane and Isoflurane in neurosurgical settings.