Irrevresible pulpitis is one of the most common conditions which involves moderate to severe dental pain. This pain is pertinent before and sometimes even after the endodontic interventions. Several pharmacological measures have been experimented to control this pain especially after completion of endodontic therapy. Therefore, this study was proposed, abstracted and conducted to assess and compare the clinical performances of Ketorol-DT and Dan-P in managing postoperative pain related to irreversible pulpitis. Materials and Methods: This study was executed in the department of conservative dentistry and endodontics wherein total 80 patients (including both male and female) were selected by systemic method of sample selection. Patients were recalled after one and two days of endodontic treatment. Patients were questioned about the overall level of satisfaction about pain control using visual analog scale (VAS). Group 1 consisted of 40 patients with Ketorol-DT and Group 2 consisted of 40 patients with Dan-P. Informed consent was obtained from all participating patients. P value less than 0.05 was taken as significant. Statistical Analysis and Results: Data was subjected to basic statistical analysis with SPSS software. Out of 80 studied patients, 52 were males and 28 were females. In Group 1, 32 patients were highly satisfied whereas 7 patients were not satisfied. In Group 2, 29 patients were highly satisfied whereas 9 patients were not satisfied. P value was highly significant for 9 non-satisfied patients. The inferences of One-way ANOVA test confirmed that level of significance (p value) was highly significant for ANOVA test conducted between groups. Conclusion: Authors concluded that both of the studied analgesics are rationally efficient however, the overall level of pain control and associated patients satisfaction was high in Ketorol-DT. Dan-P showed slightly higher number of non-satisfied cases. Authors also presume some other future studies to be executed to substantiate and validate our results.