The research is concerned with the comparative study of an important organ of the body of the living organism which called the skin between two types of mammals, namely the Baboon (Papio hamadryas) and Squirrel (Tamias striatus) on one hand, and human on the other. The study was based on the dorsal electron description of the skin and the identification and to compare the composition structures of the skin surface of the hair of the medium density to the densest in the monkey and squirrel, as well as the dead cells surrounding the hair in both the human and the monkey and the squirrel.