Background: Hypertensive disorders are major factors responsible for morbidity and mortality in pregnancy and Pre-eclampsia, a pregnancy specific disorder, is the leading cause. Despite of its prevalence and severity, the etiology of preeclampsia remains unknown, with poorly understood pathophysiology. Though the findings are heterogenous and inconsistent, several recent studies indicate that serum levels of calcium and magnesium may have a role in preeclampsia. Aim: The study is aimed to compare the levels of serum calcium and magnesium in pre-eclamptic women with that of normotensive pregnant women. Materials & Methods: Total of 120 pregnant women, of which 60 are pre-eclamptic (cases group) and 60 are normotensive (controls group), with similar demographic data were included in the study. Serum calcium and magnesium levels were measured and analyzed. Data on BMI (Body Mass Index), maternal and gestational ages and blood pressure was collected and compared between the two groups. Data was expressed as Mean ± S.D. Comparison of serum elements of both groups was performed by Independent t-test and chi square test. P value of < 0.05 was considered as statistically significant. Results: The serum calcium and magnesium levels were significantly lower in pre-eclamptic cases compared to normotensive controls. The study also showed that pre-eclamptic women had higher BMI and systolic and diastolic blood pressure, when compared to normotensive pregnant women. Conclusion: There was a significant reduction in serum calcium and magnesium levels in pre-eclamptic women when compared to normal pregnant women, suggesting the role of these nutrients in pre-eclampsia which needs further investigation.