Oxidative stress is known to produce free radicles which further damages the cell and it is also known to play an essential role in progression of carcinogenesis. In this study, lipid peroxide, that is Serum Malondialdehyde (MDA), Plasma Total antioxidant Capacity (TAC) and Serum Ceruloplasmin levels were estimated in various study and control group to evaluate its role in early diagnosis and progression of oral malignancy. Method: Total samples studied were 384. 4 groups were studied with 96 samples in each group. Group A consisted of healthy control subjects who do not have any clinical conditions or diseases. Group B involved subjects who had a history of tobacco/areca nut chewing and smoking habit. Group C consisted of potentially malignant lesion patients (PML) such as erythroplakia, leukoplakia, oral submucous fibrosis (OSMF) and lichen planus and Group D included newly diagnosed Oral Squamous cell carcinoma patients (OSCC).