Background: Mechanical Low back pain (LBP) due to hamstring tightness is a common condition affecting millions of people worldwide. Hamstring tightnessis a common finding in professional adults in the age group of 18-35 years which disturbs the spinal curvature and alters the lumbo-pelvic rhythm becoming a cause of mechanical back pain.Their sitting job profile and sedentary lifestyle being a contributory factor towards it. There is growing use of soft tissue manipulations techniques like myofascial release (MFR) among clinicians to treat hamstring tightness. Recent advances in myofascial release show that it can be administered in two ways, directly on the affected area and indirectly to some remote area. Thus, this study aimed to compare the efficacy of Direct and Indirect myofascial release in managing mechanical LBP due to hamstring tightness among professional adults.