The purpose of this study was to evaluate the impact of surgical and conservative, non-surgical treatment on functional abilities and general Health-related Quality of Life (QoL) of individuals with Spinal Cord Injury (SCI) using Spinal Cord Independence Measure scale (SCIM) and brief version of World Health Organisation Quality of Life questionnaire (WHOQOL-BREF). Methods: 50 patients with SCI were enrolled in this non-randomized clinical trial. Based on clinical symptoms and radiologic findings, patients were considered under surgical or conservative treatments. The SCIM-III and WHOQOL-BREF questionnaire was assessed at baseline and at 3, 6 and12 months. Results: 34 Patients were operated & 16 were received conservative treatments. Both study groups demonstrated treatment success, functional recovery when the baseline characteristics (p<0.001). The functional abilities SCIM III and WHOQOL-BREF score was significantly better in surgical managed group as compared to those receiving conservative therapy. Scores, T1, T2 and T3 were measured, the success rate of treatment was comparable between the study groups at 3(p=0.741), 6 (p=0.579) and 12 (p=0.858) months intervals, surgical therapy had significantly higher success at 3 month interval (p=0.031).