Background and Objectives:Induction of labor is initiating labor before spontaneous onset of labor in a viable pregnancy, is often considered when the benefits of induction outweigh the risks of continued pregnancy. Induction is commonly advised to prevent the progression of maternal illness, neonatal morbidity, or foetal demise in response to a wide variety of medical indications. There are many factors which affect successful induction. Favourable factors include younger age, multiparity, body mass index (BMI) <30, favourable cervix and fetal birth weight <3500 gms,with the most importantly being favorability of cervix assessed by Bishop’s score. Methods:The study compared vaginal misoprostol with a sequential approach (Foley catheter followed by misoprostol) for inducing labor in 130 patients each (Group A and Group B) at Dr. Ram manoharlohia institute of medical sciences, Lucknow, uttarpradesh, india. The demographic characteristics including age, parity, indication for induction of labour,augmention, Bishop’s score, no of doses of misoprostol, timing of intracervical foleys catheter, induction to delivery interval, mode of delivery and maternal / neonatal outcomes were evaluated. Results:The time from induction to delivery did not significantly differ between the groups, despite numerical variations.Differences in the mode of delivery (LSCS, NVD, instrumental) were not statistically significant.Indications for LSCS, such as foetal distress and failure to progress, were similar in both groups.Instrumental delivery was infrequently needed in both groups .Group A had a trend towards more uterine hyperstimulation (2.31%) compared to none in Group B (pvalue = 0.0815).Rates of non-reassuring foetal heart rate were comparable between the groups, suggesting consistent monitoring.APGAR scores below 7 at 1 minute and 5 minutes were similar in both groups, with no significant differences.Both induction methods (misoprostol alone and sequential approach) effectively induced labor, with outcomes influenced by patient characteristics. Conclusion:Evaluation of effective methods for induction of labour, has a very important role in obstetrics as timely and safe induction can reduce maternal and neonatal morbidity and mortality.The study reflects standard obstetric practices, highlighting the need for individualized care and flexible induction protocols to decrease the maternal and neonatal morbidity n mortality risks providing maximum benefits and positive obstetric outcomes.